Debashis Sahoo

Debashis Sahoo is an Associate Professor in Pediatrics and Computer Science and Engineering at the University of California San Diego (UCSD). His research focuses on integrating computational methods with immunology and cell biology to study macrophage polarization, stem cell biology, and disease mechanisms in conditions like inflammatory bowel disease, Alzheimer's, and cancer. He holds joint appointments in both the School of Medicine and the Jacobs School of Engineering, reflecting his interdisciplinary work.

Education: PhD in Electrical Engineering from Stanford University (2008).

Research Interests:

• Boolean network modeling of biological systems
• Macrophage plasticity in infection and inflammation
• Computational approaches to identify disease biomarkers
• Stem cell differentiation pathways in cancer
• AI-driven precision therapeutics

Key Projects:

• NIH R01AI155696: Macrophage Polarization in Response to Infections and Inflammation (Co-PI)
• NIH UG3TR003355: Precision therapeutics of inflammatory bowel disease guided by Boolean logic (PI)
• NIH R01GM138385: Annotation of cell types in human colon tissue using Boolean analysis (PI)

Publications: Over 70 peer-reviewed articles spanning computational biology, immunology, and translational medicine. Recent work focuses on AI-guided discovery of therapeutic targets in chronic inflammatory diseases and cancer.