معرفی
Dean Tantin is a Professor of Microbiology and Immunology at the University of Utah School of Medicine, where his research delves into gene regulation in T cells, stem cells, and cancer. His lab investigates how transcription factors like Oct1, Oct4, and OCA-B control stem-like properties in cells, impacting immunological memory, autoimmunity, and cancer progression.
Education:
- B.S. – University of California, San Diego
- Ph.D. – University of California, Los Angeles
Research Interests:
Dr. Tantin’s work centers on understanding how transcription factors regulate cell fate decisions, particularly in T cells and stem cells. His lab explores the roles of Oct1 and Oct4 in pluripotency and differentiation, the function of OCA-B in T cell memory and autoimmunity, and the therapeutic potential of targeting these factors in diseases like multiple sclerosis and type 1 diabetes. A major focus is on how these transcription factors control gene expression programs that endow cells with longevity, self-renewal, and rapid response capabilities.
Article Trends:
Recent publications highlight a strong emphasis on transcriptional regulation in immune cells, particularly CD4+ T cells, and stem cells. Studies explore how OCA-B and Oct factors influence T cell memory formation, autoimmune responses, and cancer development. The work bridges molecular mechanisms with translational applications, including potential drug targets for autoimmune diseases and cancer.
Laboratory and Team:
Dr. Tantin leads an active research group at the University of Utah, supported by training grants and core facilities. His lab employs molecular biology, genomics, and in vivo models to dissect transcriptional networks. While specific student names are not listed, his mentorship is evident through his involvement in bioscience PhD programs and collaborative projects.
