Dawid Makosa

Dawid Makosa is a Doctor of Philosophy Student and Research Associate at the UWA Medical School, University of Western Australia, affiliated with the UWA Centre for Medical Research and the Harry Perkins Institute of Medical Research. His research focuses on chondrocyte biology, osteoarthritis pathogenesis, and metabolic effects of high-fat diets on joint health.

His primary research interests include:

• Chondrocyte Biology (100% research focus)
• High Fat Food effects (92% research focus)
• Sirtuin proteins (92% research focus)
• Osteoarthritis mechanisms (74% research focus)
• Mitochondrial Respiration in joint tissues (51% research focus)

Makosa's publication record reveals a strong emphasis on understanding how sirtuin proteins regulate chondrocyte function and how metabolic disorders contribute to osteoarthritis development. His work employs mouse models to investigate sexually dimorphic responses to high-fat diets and examines molecular mechanisms linking obesity to joint degeneration. Recent publications in the Journal of Bone and Mineral Research and Cartilage demonstrate significant impact in the field, with his 2022 paper on Sirt3 accumulating 28 Scopus citations.

His doctoral thesis, 'Development of new single-cell genomics tools to reveal the epigenome and transcriptome dynamics in the human brain across ageing' (2025, unpublished), indicates expanding research interests into neuroscience. Makosa's work contributes to UN Sustainable Development Goals related to good health and well-being, with datasets openly shared through Figshare to promote scientific reproducibility.