David Timson

Professor David Timson is a Biochemistry academic at the University of Brighton, specializing in protein dynamics and genetic disease mechanisms. His research focuses on understanding how protein structure and mobility influence biological function, with particular emphasis on enzymes involved in metabolic disorders like galactosemia and cancer-associated proteins such as NQO1. He explores how mutations disrupt enzyme function, leading to diseases, and investigates potential therapeutic interventions through pharmacological chaperones and enzyme stabilization.

His work spans enzymology, structural biology, and parasitology, with contributions to drug discovery for helminth infections and metabolic diseases. He employs computational methods (e.g., in silico modeling) and experimental techniques to study enzyme catalysis, protein folding, and cellular stress responses in organisms like yeast and parasitic worms.

Key themes in his research include:

• Protein mobility's role in catalytic activity and disease pathogenesis
• Development of therapies targeting enzyme dysfunction in genetic disorders
• Optimization of microbial systems for biofuel production through stress tolerance engineering
• Identification of biomarkers for parasitic infections and drug efficacy

His publications reflect a multidisciplinary approach, bridging basic science and translational medicine.