معرفی
David Steven Pellman, M.D., is the Margaret M. Dyson Professor of Pediatric Oncology and Professor of Cell Biology at the Dana-Farber Cancer Institute and Harvard Medical School. His research focuses on cancer genome evolution, mitotic chromosome segregation, and nuclear envelope assembly. He has received prestigious awards including the AACR Gertrude B. Elion Award and Burroughs Wellcome Fund Clinical Scientist Award. Pellman leads NIH-funded projects such as Mechanisms Driving the Rapid Evolution of Cancer Genomes (R35CA293978, 2024–2031) and Polyploidy, Aneuploidy and Genome Stability (R01CA213404, active since 1997).
His recent publications explore chromothripsis, oncogene amplification, and mitotic DNA repair mechanisms. Pellman's work with co-authors like Cheng-Zhong Zhang and Alexander Spektor has advanced understanding of cancer chromosomal instability and CRISPR-Cas9 risks. Key concepts in his research include Mitosis, Nuclear Envelope, and Genome Stability.
- Scientific Awards
- American Cancer Society Fellowship
- AACR Gertrude B. Elion Award
- Burroughs Wellcome Fund Clinical Scientist Award in Translational Research
- Margaret M. Dyson Professorship
- Research Grants
- R35CA293978 (2024–2031): Mechanisms Driving the Rapid Evolution of Cancer Genomes
- R01CA213404 (1997–2026): Polyploidy, Aneuploidy and Genome Stability
- R37GM061345 (2000–2024): Cell Cycle Control of the Cytoskeleton
