معرفی
David McKinnon is a Professor of Neurobiology and Behavior at the Renaissance School of Medicine, State University of New York at Stony Brook. He holds a Ph.D. in Physiology from the Australian National University (1987) and has been at Stony Brook since 1991, progressing to full professor in 2005.
His research focuses on homeostatic regulation of ion channel expression, particularly in cardiac and neuronal systems. Key areas include understanding how ion channel expression adapts to genetic perturbations and environmental stressors like chemotherapy. Current projects investigate long-term stress effects on nervous and cardiovascular systems and cognitive impacts of chemotherapeutic agents.
McKinnon's lab employs conditional knockout mice to study ion channel loss in adult organisms. Notable contributions include identifying KCNQ2/KCNQ3 as molecular correlates of the M-channel and clarifying the role of Kv4.3 channels in transient outward currents. His work bridges evolutionary biology and molecular physiology, exploring how genetic changes influence physiological systems.
Publications highlight advanced techniques like single-cell RNA sequencing and computational modeling to analyze ion channel distribution and stress-induced transcriptional changes. Collaborations include Barbara Rosati (Research Assistant Professor) and Shian-Ren Liou (Postdoctoral Associate). Lab resources include the Thomas Hartman Center for Parkinson's Research and affiliate institutes.
