معرفی
David M Roberts serves as Associate Professor and Associate Chair in the Department of Biology at Franklin & Marshall College, where he teaches Cell Biology (BIO 230) and Cancer Biology (BIO 370). His research program investigates molecular mechanisms of cancer development with focus on Wnt signaling pathways and the APC tumor suppressor.
Education
- B.S., Bowling Green State University
- Ph.D., University of North Carolina at Chapel Hill
Dr. Roberts' research centers on how mutations in the Adenomatous Polyposis Coli (APC) gene drive colon cancer through dysregulation of Wnt signaling. His lab employs Drosophila models and human colon cancer cell lines to dissect APC's role in the β-catenin destruction complex, identify novel protein interactions, and explore therapeutic targets. Current projects examine APC's molecular domains, phosphorylation states, and complex assembly mechanisms.
Analysis of his publication record (2004-2015) reveals sustained contributions to understanding Wnt pathway mechanics in development and disease, with significant emphasis on APC function in destruction complex regulation. His work bridges fundamental cell biology with translational cancer research, particularly in colorectal carcinogenesis.
Advising and Funding
Dr. Roberts actively mentors undergraduate researchers, evidenced by multiple publications featuring F&M student co-authors (marked with asterisks). His laboratory is currently supported by an NIH AREA grant (R15 GM107796-01) investigating APC mechanisms in Wnt signaling.
Research Laboratory
His research group maintains dual-model systems combining Drosophila genetics with human colon cancer cell line studies to investigate Wnt pathway dysregulation. The lab focuses on protein-protein interactions within the destruction complex, centrosome regulation during mitosis, and vascular development mechanisms, with implications for colon cancer therapeutics.
