معرفی
David J. Waxman is a Professor of Biology, Medicine, and Biomedical Engineering at Boston University. He holds a PhD from Harvard University and leads a research program focusing on genomic, epigenetic, and hormonal mechanisms regulating liver gene expression, environmental chemical toxicity, and cancer immunotherapy. His work combines advanced genomic technologies like scRNA-seq and ChIP-seq with mouse models to study sex-differential gene expression, environmental toxin impacts, and anti-tumor immune responses.
Research Interests:
- Genomic/epigenetic control of liver gene expression
- Hormonal regulation via growth hormone (GH) and nuclear receptors
- Environmental chemicals and developmental toxicity
- Immunogenic chemotherapy strategies
- Non-coding RNA roles in liver physiology
Recent Work Trends: Over 150 publications highlight his focus on sex-biased gene networks, metronomic chemotherapy’s immune activation, and environmental chemical-induced epigenetic reprogramming. Key techniques include CRISPR-based epigenetic editing and single-cell transcriptomics.
Labs/Teams: Directs a multi-disciplinary lab integrating molecular biology, bioinformatics, and preclinical oncology studies. Collaborates with institutions like Harvard and MIT on translational projects.
