David C. Madoff

Dr. David C. Madoff is a Professor of Radiology & Biomedical Imaging, Medical Oncology, and Surgical Oncology at Yale School of Medicine. He serves as Vice Chair for Clinical Research and Section Chief of Interventional Radiology. His clinical expertise spans visceral vascular interventions, hepatobiliary oncology, and interventional oncology, with a global reputation for pioneering preoperative portal vein embolization to enhance liver resection safety.

• Educations:
  • B.A. from Emory University (1989)
  • M.D. from University of Pittsburgh School of Medicine (1995)
  • Residency in Radiology at SUNY Stony Brook (2000)
  • Fellowship in Vascular and Interventional Radiology at MD Anderson Cancer Center (2001)

Research Interests: Dr. Madoff focuses on interventional oncology techniques, particularly portal vein embolization, liver regeneration, and novel therapies for hepatocellular carcinoma (HCC). His work bridges clinical practice and innovation, emphasizing translational research in embolotherapy and immunotherapy combinations.

His publications (over 200 articles) and textbooks, including Clinical Interventional Oncology, reflect expertise in interventional radiology. He leads editorial roles for journals like Journal of Vascular and Interventional Radiology and Current Oncology Reports.

Awards: Elected Fellow of prominent societies (SIR, ACR, CIRSE) and recipient of BMA Medical Book Awards. Recognized as a Top Doctor by Castle Connolly for over a decade.

Grants & Teams: Active in multidisciplinary liver cancer programs at Yale, including the Liver Cancer Program and Hepatic Arterial Infusion Program. Collaborates on international trials like LEAP-012 evaluating novel HCC therapies.

Labs/Teams: Leads the Yale Interventional Oncology Lab, advancing research in image-guided therapies and AI-driven patient selection strategies.