معرفی
Dr. David B. Jacoby is a Professor in the Department of Medicine and Department of Chemical Physiology and Biochemistry at Oregon Health & Science University (OHSU) School of Medicine. Previously serving as Dean of the School of Medicine (2022-2024) and Chair of the Department of Medicine (2018-2021), he remains a tenured faculty member specializing in Pulmonary and Critical Care Medicine. Board-certified in Internal, Pulmonary, and Critical Care Medicine, his clinical and research leadership spans over three decades with significant contributions to airway disease mechanisms.
Education
- B.A., Princeton University, 1976
- M.D., New York Medical College, 1980
- Residency in Internal Medicine, Temple University Hospital, 1981-1983
- Fellowship in Clinical Pulmonary, University of California, San Francisco, 1984-1985
- Fellowship in Pulmonary Research, Cardiovascular Research Institute, UCSF, 1985-1987
Dr. Jacoby's research program pioneers the neuroimmunological basis of airway diseases, focusing on how eosinophils interact with airway nerves to drive hyperresponsiveness in asthma and chronic cough. His work reveals critical developmental programming mechanisms where maternal/grandmaternal exposures (diet, allergens) epigenetically alter offspring airway innervation and reactivity. Key investigations examine obesity-diet interactions with neural remodeling and identify novel pathways for bronchoconstriction regulation.
Analysis of his 2020-2025 publications demonstrates consistent innovation in airway neuroscience methodology and conceptual frameworks. Dominant themes include eosinophil-mediated neural plasticity, transgenerational epigenetic inheritance of airway disease, and metabolic-neural crosstalk in obesity-related asthma. His team frequently employs advanced techniques like multicolor neuronal labeling and optogenetics to dissect parasympathetic heterogeneity and sensory reflex arcs, with strong translational emphasis on therapeutic target identification.
Dr. Jacoby maintains active research within OHSU's Division of Pulmonary and Critical Care Medicine, leading a collaborative team that includes Allison D. Fryer and Matthew G. Drake. His laboratory integrates molecular, cellular, and physiological approaches to investigate airway neural biology, with particular focus on how immune cells remodel neural circuits in chronic respiratory diseases. Current work explores novel interventions targeting neural-immune interactions for treatment-resistant asthma and chronic cough.
