David B. Bensimon

David B. Bensimon is a world-leading biophysicist and Professor in the Department of Chemistry and Biochemistry at the University of California, Los Angeles, holding the prestigious Regent's Professor title since 2007. He maintains a dual academic position, serving as Directeur de Recherche at the French National Center for Scientific Research (CNRS) at the Ecole Normale Supérieure (ENS) in Paris while teaching and conducting research at UCLA for one quarter each year. His academic journey began with a Ph.D. from the University of Chicago in 1986 under Leo Kadanoff, followed by postdoctoral research at Bell Laboratories and ENS Paris.

Professor Bensimon's research spans multiple frontiers in biophysics and molecular biology, with particular expertise in single-molecule studies of nucleic acids and their proteins. His laboratory pioneered the Magnetic Trap technique for manipulating individual DNA molecules, enabling groundbreaking investigations into DNA mechanics, topoisomerase interactions, and molecular combing. His recent work has expanded into optogenetics, developmental biology using zebrafish models, and cancer research, with significant contributions to understanding how single-cell oncogene activation leads to tumorigenesis.

His research output shows remarkable breadth across disciplines, with recent publications spanning biophysics, developmental biology, cancer research, and genomic technology development. Bensimon's work on opto-chemical tools has particularly transformed how researchers can control biological processes with unprecedented spatiotemporal precision, especially in zebrafish models. His laboratory has developed photoactivatable versions of key molecular tools including Cas9 (OptoCas9) and cyclofen systems that allow precise control of protein activity at the single-cell level.

• 2007 Regent's Professor at UCLA
• 1997 Vinci of Excellence Award for phospholipid vesicle research
• 1994 Jacques Monod Prize for Molecular Combing discovery
• Special Prize of the French Physical Society for DNA mechanics work
• ICAM Fellow
• KITP-UCSB Representative

Bensimon has made significant contributions to both basic science and translational applications, co-founding Depixus for nucleic acid sequencing and epigenetic analysis. His laboratory continues to push boundaries in single-molecule biophysics while expanding into developmental biology and cancer research, with recent work demonstrating that activation of kRas in dedifferentiated cells increases tumorigenesis probability by two orders of magnitude. His mentorship has produced notable researchers including X. Michalet, and his theoretical work extends to the philosophical unification of scientific disciplines as evidenced by his book "The Unity of Science".