معرفی
Danielle L. Schmitt serves as an Assistant Professor in the Department of Chemistry and Biochemistry at the University of California, Los Angeles (UCLA), where she leads the Schmitt Lab focused on cellular metabolism organization and signaling coordination.
Her research integrates structural biology, computational modeling, and live-cell imaging to investigate spatiotemporal regulation of metabolic processes. The lab specializes in developing genetically encoded fluorescent biosensors for real-time monitoring of kinase networks and metabolite dynamics in single cells, with particular emphasis on diseases like cancer and inborn metabolic errors.
Recent publications demonstrate a consistent trajectory in biosensor innovation for metabolites (malonyl-CoA, glutamine, ATP) and kinases (AMPK, PINK1), revealing compartmentalized signaling mechanisms and metabolic enzyme assemblies during cell cycle progression. This work heavily employs fluorescence microscopy and high-throughput screening methodologies.
Funding from undisclosed sources supports the lab's interdisciplinary approach combining biochemistry, cell biology, and engineering principles to advance metabolic imaging technologies.
