معرفی
Yusuke Nasu is a full-time researcher at the Institute of Biochemistry, Academia Sinica, specializing in Lactate Metabolism, Biosensors, and Fluorescent Protein Engineering. He holds a Ph.D. and B.S. in Chemistry from The University of Tokyo (2009–2015, 2005–2009) and previously served as an Assistant Professor at The University of Tokyo (2018–2024) and a Researcher at Chugai Pharmaceutical (2015–2017). His work focuses on developing advanced biosensors for metabolite imaging and elucidating lactate-dependent signaling mechanisms.
- Research Areas: Lactate metabolism, Fluorescent protein engineering, Biosensor design, Cellular imaging, Neurochemistry
His recent publications in Nature Communications and ACS Central Science describe groundbreaking genetically encoded biosensors for lactate and calcium ion detection, enabling spatiotemporal mapping of metabolic processes. Collaborative studies with international teams have revealed lactate's role in synaptic plasticity and GPCR-lipid interactions. Current projects include multi-omics mass spectrometry for GPCR regulation and native environment preservation strategies for membrane protein analysis.
Key Contributions: Development of
- Detergent-free Lipodisq nanoparticles for high-resolution MS
- Native mass spectrometry protocols for membrane complexes
- Phosphoinositide lipid-GPCR stabilization mechanisms
