معرفی
Daniel Kümmel is University Professor of Biochemistry at the University of Münster, Germany. He heads the Kümmel Group within the Institute of Biochemistry and is an active member of the Cells in Motion Cluster of Excellence, where he contributes to the graduate program CiM-IMPRS.
Research Interests span membrane trafficking and signal transduction, with particular emphasis on the regulatory protein complexes of small GTPases. His laboratory combines structural biology—using X-ray crystallography and cryo-electron microscopy—with protein engineering and inhibitor design to elucidate how membrane targeting and vesicular transport are controlled at the molecular level.
Recent work has produced the first 3-D structures of key regulatory assemblies such as the Mon1-Ccz1 complex, revealing how Rab7/Ypt7 GTPases are activated on late endosomes and how the TSC complex senses lysosomal lipid signals to regulate mTORC1.
Scientific Awards & Honors:
Although no specific prizes are listed in the provided text, Prof. Kümmel’s sustained publication record in high-impact journals (PNAS, Nature Communications, Molecular Cell, Structure, Angewandte Chemie) attests to significant recognition by the scientific community.
Advising & Funding:
He mentors doctoral researchers within the CiM-IMPRS graduate program and participates in collaborative projects funded by the Multiscale Imaging Centre and the Cells in Motion Cluster of Excellence.
Laboratory & Collaborations:
The Kümmel Group operates state-of-the-art facilities for protein crystallization, cryo-EM, and biochemical reconstitution, collaborating closely with groups led by Christian Ungermann, Stefan Raunser, and Andrea Rentmeister to integrate structural, cell-biological, and chemical-biological approaches.
