معرفی
Daniel Kirchhofer is a Senior Fellow in Early Discovery Biochemistry at Genentech, with 28 years of tenure. His work focuses on protease research, particularly in drug discovery and therapeutic applications. Key areas include HtrA1 inhibition for age-related macular degeneration, PCSK9 antagonists for LDL cholesterol regulation, and NSP4 studies in vascular biology.
His lab employs structural biology, biochemistry, and collaborative approaches to investigate protease mechanisms. Notable achievements include identifying novel peptide inhibitors and antibodies targeting disease-relevant proteases. He mentors postdoctoral researchers, fostering their development into independent scientists.
Collaborations span multiple disciplines, integrating techniques like crystallography, phage display, and mouse models. Recent work explores NSP4's role in biological processes and HtrA1's contribution to ocular diseases.
