معرفی
Daniel Coman is an Associate Professor of Radiology and Biomedical Imaging and of Biomedical Engineering at Yale School of Medicine. His primary appointment is in the Department of Radiology & Biomedical Imaging with additional affiliations in Bioimaging Sciences, DNA Damage and Genome Integrity, Magnetic Resonance Research Center, and the Yale Cancer Center.
Dr. Coman's research focuses on developing molecular imaging methods to reveal physiological and chemical alterations underlying disease in preclinical models and clinical applications. His laboratory utilizes advanced Magnetic Resonance techniques including multi-nuclear MR Spectroscopy (1H, 13C, 31P, 19F, 23Na) and multi-modal MR Imaging approaches such as Biosensor Imaging of Redundant Deviation in Shifts (BIRDS), Chemical Exchange Saturation Transfer, calibrated fMRI, Diffusion Tensor Imaging, and Arterial Spin Labeling. His primary research interest centers on developing new MR imaging biomarkers for cancer to better understand resistance mechanisms and design novel therapies.
His recent publications demonstrate a strong emphasis on tumor microenvironment imaging, particularly pH gradients and sodium levels in cancer models. Dr. Coman has made significant contributions through the development of the BIRDS technique for mapping the acidic microenvironment of cancer. His work spans multiple disease areas including brain neoplasms, liver neoplasms, and Alzheimer's disease, with applications in understanding metabolic alterations, immune responses to therapies, and developing advanced imaging biomarkers.
Dr. Coman has received the Peterson Fellowship for graduate study in biochemistry from Yale University and maintains extensive collaborations with leading researchers including D. S. Fahmeed Hyder, Sandeep Kumar Mishra, and Julius Chapiro. His research bridges the gap between basic science and clinical applications with a strong translational focus on improving cancer diagnosis and treatment monitoring.
