معرفی
Corry-Anke Brandsma is a researcher at the University Medical Center Groningen (UMCG), affiliated with the Faculty of Medical Sciences and the Groningen Research Institute for Asthma and COPD (GRIAC). She works within the Department of Pathology and has established herself as a leading researcher in COPD pathogenesis, with particular expertise in accelerated lung aging and tissue repair mechanisms.
Brandsma completed her Master in Medical Biology at the University of Groningen (RUG) in 2003. She earned her PhD from 2003-2007 through a joint project between the Pathology and Pulmonary Diseases departments of UMCG, focusing on inflammatory responses in COPD. Following her PhD, she worked as a post-doctoral researcher from 2007-2014 on projects funded by the Dutch Lung Foundation. In 2011, she received prestigious international research fellowships from both the European Respiratory Society and the Dutch Lung Foundation to work in Professor J.C. Hogg's laboratory in Vancouver, Canada. She was appointed as a staff member in the Department of Pathology at UMCG in 2014.
Her primary research focus centers on the role of accelerated lung aging and abnormal tissue repair in COPD pathogenesis. She employs a comprehensive 'multi-omics' approach that integrates genomic, transcriptomic (including miRNA), and proteomic data to identify causal molecular networks in COPD. Her work specifically investigates cellular senescence, extracellular matrix dysregulation, and impaired tissue repair mechanisms in COPD patients. She utilizes primary lung cells and lung tissue from well-characterized COPD patients and non-COPD control subjects to unravel these complex molecular pathways.
Analysis of her recent publications reveals a consistent focus on molecular mechanisms underlying COPD, with particular attention to cellular senescence, extracellular matrix changes, and tissue repair processes. Her work bridges basic science with clinical applications, exploring how aging processes contribute to COPD development and progression. The multi-omics approach she employs allows for comprehensive understanding of disease mechanisms across multiple biological levels.
- Osteocytokine RANKL signalling as a novel pathway to achieve alveolar proliferation (2022)
- European Respiratory Society International Research Fellowship (2011)
- Dutch Lung Foundation Fellowship (2011)
Brandsma actively supervises PhD students, with records indicating involvement in the supervision and examination of multiple doctoral candidates. Her research has been supported by significant grants from the Dutch Lung Foundation and other funding bodies. She maintains active collaborations within the Groningen Research Institute for Asthma and COPD and with international partners, as evidenced by her Vancouver fellowship and ongoing research networks. Her work contributes to Sustainable Development Goal 3: Good Health and Well-being.
She leads research within the GRIAC institute, focusing on molecular mechanisms of COPD pathogenesis. Her laboratory work involves primary cell cultures, tissue analysis, and multi-omics approaches to understand disease mechanisms. She collaborates extensively with clinicians and researchers across pulmonary medicine, pathology, and molecular biology disciplines to translate basic science findings into clinical applications.
