Claire Aline Guerillon

Claire Aline Guerillon serves as a Special Consultant and Guest Researcher at the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, within the Mailand Group led by Professor Niels Mailand. Her work focuses on molecular mechanisms of genome stability and cancer pathways through protein signaling research.

Her core research investigates post-translational modifications, particularly SUMOylation, and its dual roles in DNA damage response and tumor suppression. Key contributions include elucidating how multisite SUMOylation regulates DNA polymerase η activity at lesion sites to prevent mutagenesis and demonstrating SUMOylation's control over ING1b tumor suppressor function in transcriptional regulation. This work bridges fundamental biochemistry with cancer therapeutics development.

Publication analysis (2014-2020) reveals consistent specialization in SUMOylation across two major domains: DNA repair mechanisms (2020 Journal of Biological Chemistry study on translesion synthesis regulation) and cancer biology (2014 Carcinogenesis paper on tumor suppressor modulation). Both studies establish SUMOylation as a critical switch for protein interactions in genome maintenance pathways, with implications for targeted cancer treatments.

No scientific awards were documented in available sources.

Student advising and grant funding details are not specified in current records, though her collaborative publications indicate active research group participation.

She operates within the Mailand Group at the Center for Protein Research, a specialized unit investigating protein networks in DNA damage response, utilizing advanced proteomics and cell biology methodologies to address genome integrity questions.