Saskia Hoffmann

Saskia Hoffmann is an Associate Professor at the Novo Nordisk Foundation Center for Protein Research (CPR) at the University of Copenhagen, where she leads research in the Mailand Group. She has held this position since October 2019 and maintains dual affiliation as both Associate Professor and Guest Researcher at CPR.

Her academic credentials include:

• PhD in Biochemistry (2013-2016) from the University of Copenhagen, CPR, under Professor Niels Mailand with thesis on 'Functions of ubiquitin ligases in responses to replication stress and DNA damage'
• Master's in Biochemistry (2010-2012) from the University of Copenhagen supervised by Associate Professor Claus Storgaard Sørensen
• Bachelor's in Biochemistry (2007-2010) from the University of Leipzig, Germany, supervised by Professor Kurt Engeland

Dr. Hoffmann's research program focuses on cellular responses to DNA damage and replication stress, with particular emphasis on understanding how cells counteract genotoxic insults to maintain genome stability. Her current work investigates the molecular link between human proteases and cellular surveillance pathways, revealing critical implications for human health and disease. Her research spans:

• Cell Biology mechanisms underlying genome maintenance
• Genome stability preservation pathways
• DNA Damage Response systems
• DNA Replication processes under stress conditions
• Protease functions in cellular surveillance

Analysis of her publication record demonstrates a consistent research trajectory focused on DNA damage response mechanisms, protein modification systems (particularly ubiquitination and SUMOylation), and their roles in maintaining genome integrity. Her work frequently explores how defects in these pathways contribute to human diseases including genetic disorders and cancer, with several publications appearing in high-impact journals such as Nature Structural and Molecular Biology, Nature Communications, and Molecular Cell.

Dr. Hoffmann has established herself as a significant contributor to the field of genome maintenance research, with her work on proteases and DNA damage response pathways opening new avenues for understanding disease mechanisms and potential therapeutic approaches.