معرفی
Claes Wickström is an Associate Professor and Head of Division at the Faculty of Odontology, Malmö University, Sweden. His research primarily focuses on oral microbiology and biofilm formation within the context of dental health and disease. He is affiliated with the Biofilms Research Centre for Biointerfaces, a multidisciplinary research center examining the interface between life and materials.
Wickström's research interests center on oral biofilms, salivary proteins, and their role in maintaining oral health or contributing to dental diseases. His work investigates how salivary components like MUC5B influence bacterial adhesion, biofilm formation, and microbial metabolism in the oral cavity. He explores the complex interactions between host factors and oral microorganisms, particularly in relation to dental caries development and prevention.
His recent publications reveal a strong focus on the metabolic interactions within early oral biofilms, particularly examining how salivary mucins modulate bacterial glucose metabolism. His research demonstrates how host-derived factors like MUC5B can regulate biofilm composition and function, potentially maintaining eubiosis and preventing dysbiosis that leads to dental caries.
Wickström leads several significant research projects including Modulation of immune responses by biofilm-derived and niche-adapted oral streptococcal populations, Simultaneous Scattering and Tribological Investigations of Sheared Thin Soft Matter Films under Low Pressure, and the doctoral project Enzymatic activity in oral biofilms – biotechnological applications and putative predictive biomarkers for oral health and disease.
He is actively involved with the Biofilms Research Centre for Biointerfaces, where his team employs advanced methodologies including NMR-based metabolomics, flow-cell biofilm models, and molecular characterization techniques to investigate oral microbial ecosystems. His collaborative work spans multiple disciplines, connecting dentistry with microbiology, biochemistry, and materials science to develop a comprehensive understanding of oral health mechanisms.
