Christopher J. Chang

Christopher J. Chang is the Edward and Virginia Taylor Professor of Bioorganic Chemistry at Princeton University's Department of Chemistry. His research focuses on chemical biology, catalysis, and inorganic chemistry, with an emphasis on transition metal signaling, activity-based sensing, and drug discovery. He leads the Chang Lab, which develops innovative chemical tools to study metal-dependent biological processes, including copper's role in neurobiology and cancer, formaldehyde's role in epigenetic regulation, and redox-driven protein function.

His work integrates organic, inorganic, and biological chemistry, enabling discoveries in imaging, proteomics, and precision medicine. Notable achievements include pioneering activity-based sensing platforms for copper and reactive metabolites, revealing metalloplasia in cancer, and developing copper-specific therapies.

Christopher Chang has received over 50 prestigious awards, including the Guggenheim Fellowship and the Howard Hughes Medical Institute Investigatorship. His lab's infrastructure includes advanced analytical instruments, synthetic chemistry facilities, and cell culture capabilities, supported by grants from NIH, NSF, and industry partnerships.

• Awards: ACS Bader Award (2024), Ivano Bertini Award (2022), Blavatnik National Award (2015)
• Lab Focus Areas: Transition metal signaling, copper-dependent biology, formaldehyde metabolism, redox drug discovery
• Key Technologies: Activity-based sensors, imaging probes, bioconjugation methods