معرفی
Professor Chris F Inglehearn is Professor of Molecular Ophthalmology at the University of Leeds, Faculty of Medicine and Health, where he heads the Division of Molecular Medicine. He established the Leeds Vision Research Group and leads cross-disciplinary programmes on inherited blindness, dental genetics and psychosis.
Education:
- BSc Biological Sciences (2:1 Hons), University of Edinburgh, 1984
- PhD Molecular Genetics, University of Edinburgh, 1988
Research interests span genomic dissection of inherited retinal dystrophies, amelogenesis imperfecta and neurodevelopmental disorders. His laboratory deploys high-throughput sequencing, bioinformatics, genome editing and stem-cell models to identify disease genes, elucidate pathogenic mechanisms and develop diagnostic assays.
Recent work has discovered novel ubiquitously expressed splicing-factor defects underlying tissue-specific retinal disease, identified over a dozen genes for amelogenesis imperfecta, and created the first UK NHS diagnostic service for this condition. International collaborations include coordination of the EU EyeTN training network and leadership roles in the UK Retinal Disease Consortium and Genomics England Clinical Interpretation Partnership.
Selected professional service:
- Chair, Management Group, European Retinal Disease Consortium (2018-2021)
- Member, Genomics England GeCIP Hearing & Sight Domain
- Chair, Candlelighters Science Advisory Board (2003-2010)
- Wellcome Trust Molecular & Cellular Neuroscience Panel (2004-2008)
He has supervised 30 PhD students to completion, delivered undergraduate and MSc teaching on human inherited disease, and published >213 peer-reviewed articles.
