Chia-Lung Wu

Dr. Chia-Lung Wu is a Professor and Principal Investigator at the University of Rochester Medical Center (URMC), leading the Wu Lab focused on molecular mechanisms governing musculoskeletal tissue development and disease. His lab integrates bioengineering, genomics, and biomechanical models to study cartilage and bone biology, with applications in regenerative medicine. Key research areas include stem cell therapy optimization, epigenetic regulation, and mechanosensory ion channel dysfunction in skeletal disorders.

Collaborating with experts like Dr. Brian Giordano (Orthopaedics) and Dr. Farshid Guilak (Biomedical Engineering), Wu’s lab explores TRPV4 ion channel pathophysiology and osteoarthritis mechanisms. The team employs cutting-edge techniques such as single-cell transcriptomics and CRISPR-Cas9 genome editing to advance tissue engineering and disease modeling. Current initiatives aim to improve therapies for musculoskeletal disorders through personalized approaches and gene therapy innovations.

The lab actively recruits postdoctoral researchers, graduate students, and undergraduates, offering training in stem cell biology, next-generation sequencing, and bioinformatics. Located at 601 Elmwood Ave, Rochester, NY, the lab’s work is funded by NIH grants and focuses on translating basic research findings into clinical solutions for cartilage repair and metabolic joint diseases.