معرفی
Farshid Guilak is the Mildred B Simon Research Professor of Orthopaedic Surgery at Washington University School of Medicine. His interdisciplinary research program investigates osteoarthritis mechanisms, focusing on obesity-related inflammation, cartilage mechanobiology, and stem cell-based regenerative therapies.
Research Focus:
- Obesity-inflammation-osteoarthritis axis
- Mechanosensitive ion channels in cartilage
- Stem cell engineering for joint regeneration
- Digital immunoassays for biomarker detection
Key Discoveries: Identified Piezo1 mechanotransduction pathways in osteoarthritis pathogenesis and adipose tissue's regulatory role in joint degeneration.
Clinical Translation: Develops 'smart' engineered tissues with synthetic gene circuits for autonomous disease-responsive therapy.
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