Chad Grueter

Chad Grueter, PhD, is an Associate Professor of Internal Medicine-Cardiovascular Medicine and Vice Chair for Research in the Department of Internal Medicine at the University of Iowa. His laboratory focuses on understanding transcriptional and posttranscriptional mechanisms disrupted in heart disease, particularly the role of the Mediator complex components (MED13, CDK8, MED1) in cardiac metabolism and heart failure. He holds affiliations with the Cardiovascular Research Center and Fraternal Order of Eagles Diabetes Research Center.

• Education: PhD in Molecular Physiology and Biophysics from Vanderbilt University (200?), followed by postdoctoral training at UT Southwestern Medical Center.

Research interests include how the heart regulates whole-body metabolism through novel signaling pathways, such as those involving miR-208a and MED13. His work utilizes mutant mouse models, proteomic, and bioinformatic approaches to study cardiac transcriptional responses to stress. Recent studies highlight the interplay between cardiac signaling and systemic metabolism, with implications for obesity prevention and heart failure therapies.

Selected publications span topics like PI3Kβ's dual roles in cardiac remodeling, Mediator complex subunit functions, and cardiac-secreted factors' metabolic effects. These studies collectively emphasize molecular mechanisms of heart disease and potential therapeutic targets.

Dr. Grueter's lab actively investigates stress-adaptive transcription regulators (e.g., junctophilin-2) and the role of epigenetic modifications in cardiac dysfunction. His research bridges basic science and translational medicine, aiming to uncover novel pathways for clinical intervention.