معرفی
Celia Santi, MD, PhD is the James P. Crane Professor in the Department of Obstetrics and Gynecology at Washington University School of Medicine and a faculty member in the Center for Reproductive Health Sciences. Her academic journey includes an MD from Universidad de la Republica-Uruguay, a PhD in Biophysics-Physiology from UNAM, Mexico, and postdoctoral training at University of British Columbia and Washington University.
Her research program focuses on ion channel physiology in reproductive systems, with particular emphasis on potassium and calcium channels in sperm physiology. Key areas include sperm capacitation, acrosome reaction, and the role of SLO and CatSper channels in fertilization. Her work bridges molecular biophysics with clinical reproductive medicine, investigating how ion channel dysfunction contributes to infertility.
Analysis of her recent publications reveals consistent focus on membrane potential regulation in sperm and myometrial cells, with increasing translational applications in contraceptive development and fertility diagnostics. Her work demonstrates strong integration of electrophysiology, molecular biology, and clinical reproductive science across species from mice to humans.
- NIH R01 Grant for ion channel research
- NIH R21 Grant for sperm physiology studies
- James P. Crane Professorship (endowed chair)
- Member of Sociedad de Biofisicos Latinoamericanos
- Member of American Society of Andrology
Dr. Santi's laboratory has secured continuous NIH funding supporting research on sperm ion channels and their role in fertility. Her collaborative work spans multiple departments including Physiology, Biomedical Engineering, and Obstetrics. Current projects investigate membrane potential dynamics, contraceptive targets, and diagnostic applications of sperm physiology.
The Santi Laboratory maintains active collaborations with clinical reproductive medicine teams, applying basic science discoveries to infertility diagnostics. Current research directions include development of sperm function predictive algorithms and exploration of ion channels as targets for non-hormonal contraceptives.
