معرفی
Cathleen R. Carlin is a Professor in the Department of Molecular Biology and Microbiology and the Department of Physiology and Biophysics at the School of Medicine, Case Western Reserve University. She holds a dual faculty appointment and is a member of the Molecular Oncology Program at the Case Comprehensive Cancer Center. Her research focuses on understanding intracellular membrane trafficking mechanisms and their roles in disease and viral infections. Key areas include EGF receptor (EGFR) trafficking in epithelial carcinomas, cholesterol homeostasis regulation by adenoviral proteins, and therapeutic targets for diseases like polycystic kidney disease.
Her work combines cell biology, virology, and cancer research to investigate how pathogens and cancer disrupt cellular processes. Notable projects include studying EGFR sorting defects in triple-negative breast cancer progression and developing models to translate findings from cell culture to in vivo tumor environments. She has also contributed to understanding how adenovirus proteins like RIDα modulate endosomal cholesterol pathways, offering insights into treating Niemann-Pick Type C disease.
Dr. Carlin’s research highlights interdisciplinary approaches, linking viral mechanisms, cellular homeostasis, and oncogenesis. Her findings have implications for therapies targeting membrane trafficking defects in diseases such as cancer, neurodegeneration, and genetic disorders.
