Catherine C Kaczorowski

Catherine C Kaczorowski is the Elinor Levine Professor of Dementia Research and Professor of Neurology at the University of Michigan Medical School. She leads a laboratory focused on genetic and cellular mechanisms promoting resilience to Alzheimer's disease and cognitive aging. Her work integrates genomic, anatomic, and behavioral approaches across species, leveraging genetically diverse mouse models to advance personalized medicine strategies.

Education:

• PhD in Neuroscience, Northwestern University Institute for Neuroscience (2006)
• BA from University of Wisconsin–Milwaukee (2000)
• Additional training: Kern Innovation Fellow at Medical College of Wisconsin (2012)

Research interests center on identifying molecular pathways that confer protection against neurodegenerative diseases, with emphasis on systems biology approaches and cross-species validation. Recent work highlights discoveries in lysosomal enzymes (PLD3), genetic modifiers of disease progression, and sex-specific resilience mechanisms.

Key affiliations include the Center for Computational Medicine and Bioinformatics and Precision Health Initiative. Her lab's publications span drug efficacy testing, transcriptome analysis, and novel mouse model development, emphasizing genetic diversity's role in disease outcomes.

Grants and mentorship activities are extensive but not explicitly detailed here. Collaborations focus on translational research bridging basic science and clinical applications in dementia therapy development.