معرفی
Professor Carrie Ambler is a Professor in the Department of Biosciences at Durham University. Her research focuses on understanding how cell-cell interactions regulate skin stem cells, particularly investigating Notch signaling pathways and their roles in skin homeostasis, hair follicle maintenance, and inflammatory skin diseases. She employs proteomic and genomic approaches to study epithelial-mesenchymal interactions, with a focus on translational applications for skin disorders.
Her work demonstrates that Notch signaling downstream of WNT/β-catenin pathways regulates keratinocyte differentiation and hair cell maturation. Current projects include elucidating Notch pathway transmission in skin cells and its role in diseases like tufted hair folliculitis. She collaborates across disciplines, integrating chemical biology (e.g., photoactivatable antibacterial agents) and advanced imaging techniques like Raman spectroscopy for cancer diagnostics.
Key contributions include identifying Jagged1 as a WNT target and revealing Notch's role in recruiting innate lymphoid cells for wound repair. Her lab also develops synthetic retinoids (e.g., EC23) to modulate epidermal proliferation. Supervised research includes Masi Yousefi's PhD on skin repair mechanisms.
Awards: None explicitly listed in provided texts.
Her lab's future work aims to bridge basic science findings with clinical applications in dermatology and oncology, emphasizing translational research in skin regeneration and targeted therapies.
