Caroline Shamu

Caroline Shamu is an Assistant Professor at Harvard Medical School with dual appointments in the Department of Radiology at Massachusetts General Hospital and the Department of Biological Chemistry and Molecular Pharmacology. She serves as Scientific Director for HMS Research Cores and Technology and directs the ICCB-Longwood Screening Facility, which provides high-throughput small molecule and RNAi screening resources. Dr. Shamu earned her Ph.D. in Cell Biology from the University of California San Francisco and completed postdoctoral training in the Department of Cell Biology at Harvard Medical School.

Her research focuses on:

• Development of high-throughput screening technologies (RNAi, small molecules)
• Assay design and optimization for complex biological systems
• Bioinformatics infrastructure for large-scale data integration
• Standardization of metadata and data exchange protocols
• Implementation of screening repositories and open-source LIMS

Her publications demonstrate extensive work in screening methodology innovation, with consistent focus on data standardization, imaging platforms, and translational applications in cancer research and drug discovery. Recent articles emphasize computational approaches for off-target effect prediction and interoperable data frameworks.

Leadership & Infrastructure: Dr. Shamu oversees technology cores supporting academic screening initiatives and develops open-source tools like the Screensaver LIMS. Her work bridges experimental biology with data science to advance collaborative research.