معرفی
Xiang Wang is an Associate Professor in the Department of Chemistry at the University of Colorado Boulder, where he integrates synthetic organic chemistry, biochemistry, and molecular biology to develop small-molecule probes for biological research and disease treatment.
His educational background includes:
- Ph.D. from Boston University (2005)
- Postdoctoral training at Harvard University and the Broad Institute of Harvard & MIT (2008)
Dr. Wang's research spans three primary domains:
- Bio-Inspired Synthesis: Developing novel synthetic methodologies for biologically active natural products targeting anti-cancer, antibacterial, and antiviral applications while identifying cellular targets.
- Chemical Epigenetics: Designing small-molecule modulators of chromatin-modifying enzymes (KDMs, TETs) through structure-based design and screening to study epigenetic regulation in cancer and development.
- High-Throughput Screening: Collaborating with biologists to discover probes preventing tumor suppressor degradation, enhancing cellular reprogramming, and disrupting bacterial persistence via CU-Boulder's HTS core facility.
His publication record reveals a strategic focus on translating chemical biology into therapeutic solutions, particularly in epigenetic drug discovery and antibiotic resistance reversal, with methodologies emphasizing interdisciplinary integration.
Dr. Wang directs the Wang Group from laboratory facilities in Cristol Chemistry (rooms 200, 214, 263), maintaining active collaborations across biological disciplines to advance probe development and mechanistic studies.
