معرفی
Carole LINSTER is an Associate Professor in Biochemistry at the University of Luxembourg's Luxembourg Centre for Systems Biomedicine (LCSB), leading the Enzymology & Metabolism group. Her research focuses on understanding metabolic pathways, metabolite repair mechanisms, and their roles in neurodegenerative and metabolic disorders. She investigates how cellular metabolism interacts with disease progression, particularly in mitochondrial dysfunction and neurodevelopmental syndromes.
Key research areas include:
- Metabolite damage and repair pathways
- Enzymatic mechanisms in metabolic disorders
- Systems biomedicine approaches to disease biomarkers
- Neurological and metabolic perturbations in genetic disorders
Her recent work highlights breakthroughs like CLYBL's role in vitamin B12 homeostasis, ketogenic diet effects on colorectal cancer via microbiome interactions, and NAXD deficiency's neurodegenerative consequences. She employs advanced metabolomics, yeast models, and clinical studies to bridge basic science and translational medicine.
Publications span topics from mitochondrial disease biomarkers to drug repurposing for epilepsy. Her lab integrates systems biology and biochemical approaches to uncover novel therapeutic targets, emphasizing metabolite-driven mechanisms in health and disease.