معرفی
Carlos Aguilar is an Associate Professor in the Department of Biomedical Engineering at the University of Michigan, where he investigates fundamental mechanisms of muscle stem cell dysfunction and cancer metastasis. His work spans aging biology, epigenetics, and regenerative medicine, with a focus on translating findings to clinical applications.
- Research Priorities: Muscle stem cell aging, blood-brain barrier modeling, lipid mediators in tissue repair, microgravity effects on bone cells, and cancer brain metastasis
- Technologies: Microfluidic devices, engineered hydrogels, genome topology analysis, lipidomic profiling
His lab has published extensively on age-related stem cell decline (2023-2025) and developed organ-on-a-chip models for studying cancer spread to the brain. Collaborations include the Merajver Lab and Space Tango for microgravity research.
Scientific contributions include identifying retinoic acid as a regulator of mitochondrial function in aging muscle, and Dkk1 as a key mediator of early brain metastasis. His team also explores epigenetic switches linking inflammation to ferroptosis in aged stem cells.
Carlos Aguilar's group has trained graduate students including Jesus Castor-Macias, Jacqueline Larouche, and Pamela Duran. They employ single-cell sequencing to analyze macrophage roles in regenerative vs fibrotic healing outcomes across musculoskeletal injuries.
