معرفی
Carina I Holmberg is a University Lecturer at the Department of Biochemistry and Developmental Biology, University of Helsinki, where she serves as a Supervisor in the Doctoral Programme in Biomedicine. Her research integrates biochemistry, cell biology, and molecular genetics to investigate proteasome function, autophagy, and neurodegenerative disease mechanisms using model organisms like Caenorhabditis elegans and murine systems.
Her core research interests include:
- Ubiquitin-proteasome system dynamics and deubiquitinating enzymes
- Autophagy regulation in cellular homeostasis
- Molecular mechanisms of Parkinson's disease
- Tissue-specific stress responses
- Translational applications in cancer and neurodegeneration
Recent publications demonstrate a consistent focus on proteostasis dysregulation in disease contexts, with 2021-2025 work examining nicotinamide riboside therapeutics in Parkinson's models, BAP1 cancer mutations, and autophagy-proteasome crosstalk. Her research employs genetic, biochemical, and live-imaging approaches to uncover fundamental mechanisms.
Active research funding includes multiple grants from foundations:
- Liv och Hälsa (€30,000–60,000; 2023–2026)
- Magnus Ehrnrooths Stiftelse (€8,000–10,000; 2023–2026)
She actively contributes to academic service as a dissertation opponent, thesis supervisor, and host for international researchers. Her laboratory investigates proteasome subcellular localization and develops novel models for neurodegenerative disease research.
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