معرفی
Caleigh Mandel-Brehm is an Assistant Professor in the Department of Pathology at Yale School of Medicine. Her research focuses on the molecular and cellular mechanisms underlying neuro-immune interactions and human autoimmune pathology.
Dr. Mandel-Brehm's research interests include:
- Neuro-immune interactions
- Autoimmune pathology
- Molecular neuroscience
- Behavioral disorders
- Movement disorders
- Psychiatric illness
Her work investigates how the intricate relationship between the nervous system and immune system—critical for normal brain function—can become disrupted, leading to autoimmune conditions that break tolerance to self-proteins. Despite the significance of studying these interactions between two complex biological systems, fundamental questions remain about how immune cells enter the brain and cause specific neuronal dysfunction.
Dr. Mandel-Brehm emphasizes mentorship as a core component of her laboratory. She provides comprehensive training in research methodology, scientific writing, critical literature review, and presentation skills to prepare students for successful careers in academia or industry. Her approach to mentorship is informed by her own positive experiences with strong guidance beginning in undergraduate studies.
Her laboratory is housed within the Department of Pathology at Yale School of Medicine, located in the Brady Memorial Laboratory at 310 Cedar Street, Floor 3, Room 363, New Haven, CT 06510, which serves as a vibrant scientific community focused on mechanisms of cancer and autoimmune disease.