C. Michel Zwaan

C. Michel Zwaan is a Full Professor in the Department of Pediatrics at Erasmus MC, a leading academic medical center in the Netherlands. His work is primarily focused on pediatric hematological malignancies, particularly acute leukemias in children and adolescents. He is actively engaged in clinical and translational research, with a strong emphasis on improving treatment outcomes through pharmacokinetic modeling, novel therapeutics, and population-based survival analyses.

His research interests span pediatric oncology, acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), pharmacokinetics, treatment optimization, and infectious complications during chemotherapy. His work integrates clinical data with molecular and genetic insights, especially in high-risk and relapsed leukemias. He has contributed significantly to understanding leukemia in special populations, including those with Down syndrome.

The most recent publications highlight trends in targeted therapy (e.g., venetoclax), precision dosing in transplantation, infection control during AML treatment, and large-scale survival studies across Europe. These works reflect a strong commitment to evidence-based, data-driven improvements in pediatric cancer care.

Scientific Contributions and Supervision:

• Supervised 19 research projects or theses, indicating active mentorship of junior researchers and students.
• Extensive publication record with 331 research outputs, including original articles, reviews, editorials, and an inaugural speech.
• Active in multinational collaborations, contributing to population-based studies like EUROCARE-6 and global clinical trials in pediatric AML.

Research Infrastructure:

• Works within the Department of Pediatrics at Erasmus MC, a major hub for pediatric oncology research and clinical care.
• Engaged in networked research across European institutions, particularly in epidemiological and clinical trial consortia.
• Part of a collaborative environment involving pharmacokinetic modeling, stem cell transplantation, and molecular diagnostics in pediatric leukemia.