Bruce Mickey

Dr. Bruce Mickey is Vice Chairman of the Department of Neurosurgery and holds the William Kemp Clark Chair in Neurological Surgery at the University of Texas Southwestern Medical Center. He directs the Annette Straus Center for Neuro-Oncology and specializes in surgical management of intracranial tumors, epilepsy surgery, and radiosurgery. He completed neurosurgical residency at UT Southwestern and a fellowship at Rigshospitalet, Copenhagen. Dr. Mickey is an active member of the American Association of Neurological Surgeons and North American Skull Base Society.

Research Interests: His work focuses on neuro-oncology, glioblastoma biology, molecular imaging techniques (e.g., MRI-based deep learning for tumor classification), and translational applications of spatial transcriptomics. He investigates immune landscapes in cancer, drug repurposing (e.g., arsenic trioxide), and animal models of brain tumors. Recent studies explore sex-based differences in glioblastoma gene expression and T-cell infiltration dynamics.

• Key Projects: Development of non-invasive biomarkers for brain tumor molecular classification, preclinical models of temozolomide-resistant glioblastoma, and optimization of radiosurgery outcomes for brain metastases.

Labs/Teams: Leads the Annette Straus Center for Neuro-Oncology, collaborating on translational research bridging clinical neurosurgery and molecular oncology.