Brian M Paegel

Brian M Paegel is a Professor at the University of California, Irvine (UCI), holding appointments in three schools: School of Pharmacy & Pharmaceutical Sciences, School of Physical Sciences, and The Henry Samueli School of Engineering. He also serves as the Associate Dean of Research in the School of Pharmacy & Pharmaceutical Sciences. His academic background includes a B.S. in Chemistry from Duke University (1998) and a Ph.D. in Chemistry from UC Berkeley (2003).

• Research Focus: Drug discovery, microfluidics, combinatorial chemistry, and DNA-encoded libraries. His work aims to revolutionize high-throughput screening (HTS) through miniaturized, cost-effective platforms.
• Awards: NIH NRSA Postdoctoral Fellow, NIH Pathway to Independence Award, NIH Director's New Innovator Award, NSF CAREER Award, and NIH MIRA.

His research integrates microfluidics to develop next-generation drug discovery tools, emphasizing distributed HTS using DNA-encoded libraries. This approach aims to make drug discovery as accessible as DNA sequencing.

Key contributions include the development of microfluidic devices for DNA sequencing and the design of droplet-scale pharmacokinetic assays. His lab, the Paegel Lab, focuses on translating genomic insights into therapeutic solutions.