Brian D. Crompton

Brian D. Crompton, MD is an Assistant Professor in Pediatrics at Harvard Medical School and a key researcher at the Dana-Farber/Boston Children's Cancer and Blood Disorders Center. As a Physician and Research Co-Director of the Solid Tumor Center, he specializes in pediatric sarcomas and genomic approaches to cancer treatment.

• Harvard Medical School: Assistant Professor (2023-present)
• Dana-Farber/Boston Children's: Research Co-Director, Solid Tumor Center

Research Focus: Dr. Crompton's work centers on pediatric solid tumors, particularly Ewing sarcoma, osteosarcoma, and Wilms tumor. His studies explore circulating tumor DNA, germline genetic variants, and targeted therapies through both clinical trials and laboratory investigations.

Recent Publication Trends: His research emphasizes liquid biopsy applications, molecular profiling of pediatric cancers, and genomic biomarkers for prognosis and treatment response. Key articles examine radiomic variability in sarcomas, TRIP13 inhibition in Wilms tumor, and MYC amplification in osteosarcoma.

Key Collaborations: Dr. Crompton works extensively with the Children's Oncology Group, conducting multi-center clinical trials like ADVL1823 and ARST1431. His research integrates precision medicine approaches with traditional chemotherapy regimens.