Brian C. Miller

Brian C. Miller, MD, PhD, is an Assistant Professor in the Department of Medicine-Oncology at the UNC School of Medicine. As a member of the UNC Lineberger Comprehensive Cancer Center, his research focuses on understanding how tumors evade the immune system and developing novel myeloid-directed immunotherapies to enhance anti-cancer immunity. Using single-cell profiling and functional genomics, he investigates immune cell dynamics in resistant tumors.

• Department: Medicine-Oncology
• University: University of North Carolina at Chapel Hill
• Lab: The Miller Lab

Dr. Miller's work emphasizes tumor immunology, with a particular interest in myeloid cell regulation, T cell exhaustion, and immune checkpoint blockade. His lab employs mouse models, human tumor samples, and CRISPR screening to identify therapeutic vulnerabilities in resistant cancers.

Recent research trends include leveraging epigenetic modifications to improve T cell function, studying metabolic influences on tumor immunity, and exploring clonal hematopoiesis in cancer treatment outcomes. His publications span top journals like Nature, Cell, and Cancer Immunology Research.

• Scientific Awards:
  • Melanoma Research Alliance Young Investigator Award (2024)
  • V Scholar Grant (2024)
  • Burroughs Wellcome Fund Career Award (2021)
  • NCI K08 Grant (2020)

Dr. Miller has received multiple grants for immunotherapy research and mentors in cancer immunology, with a focus on myeloid cell therapies. His work is highlighted in the Miller Lab, which employs cutting-edge technologies to address therapeutic resistance in melanoma and prostate cancer.