Brian Appleby

Brian Appleby, MD is an Associate Professor in the Departments of Neurology, Psychiatry, and Pathology at Case Western Reserve University School of Medicine. He serves as Director of the National Prion Disease Pathology Surveillance Center, Medical Director of the Creutzfeldt-Jakob (CJD) Foundation, and Chair of the Cleveland Chapter Alzheimer’s Association Professional Advisory Board. His roles span clinical practice, academic research, and public health surveillance.

Dr. Appleby received his M.D. from Georgetown University School of Medicine (2003) and completed residencies and fellowships at Johns Hopkins Hospital, including a Psychiatry Residency (2007) and Geriatric Psychiatry Fellowship (2008).

His research focuses on prion diseases (e.g., CJD), frontotemporal lobar degeneration, and young-onset dementias, with an emphasis on neuropsychiatric manifestations. He actively contributes to surveillance and diagnostic efforts through the National Prion Disease Pathology Surveillance Center.

While no specific grants or advising details are listed, his professional roles indicate leadership in academic and clinical collaborations. His work bridges neurology, psychiatry, and pathology, addressing critical gaps in understanding neurodegenerative conditions.