Boris Kholodenko

Boris Kholodenko is a Professor at Yale School of Medicine, specializing in systems biology and cancer research. His work focuses on understanding cellular signaling networks, drug resistance mechanisms, and cell state transitions in cancer. Key research areas include computational modeling of signaling pathways, ERK signaling inhibition, and therapeutic target identification in oncology.

• Research Interests: Cell signaling, cancer biology, systems biology, drug resistance, computational modeling, and network dynamics.
• Recent Publications Highlight: Analysis of endothelial cell cycle regulation in vascular remodeling (Science Advances, 2025), and development of drug combinations for RAS-mutant leukemia (Blood, 2024).
• Collaborations: Works with researchers like Oleg Rukhlenko, William Kolch, and Martin Schwartz on cancer cell state transitions and signaling networks.

His articles emphasize interdisciplinary approaches combining systems biology with clinical oncology, particularly targeting ERK signaling and therapeutic strategies to reverse pathological cell states.