Berkley Gryder

Berkley Gryder, PhD is an Assistant Professor in the Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine, with secondary appointments in the Case Comprehensive Cancer Center and the Angie Fowler Adolescent and Young Adult Cancer Research Initiative. His interdisciplinary work bridges chemistry, molecular biology, and computational science to investigate cancer epigenetics and transcriptional control.

Research areas include:

• 3D genome organization in cancer
• Nuclear condensate formation
• Chemical strategies targeting transcription
• Single-cell epigenetic analysis
• Machine learning applications in genomics
• Novel wet-lab technologies

Recent publications focus on nuclear phase separation, chromatin architecture in rhabdomyosarcoma, and chemical approaches to disrupt oncogenic transcriptional programs. Collaborations span medical oncology and medicinal chemistry teams across multiple institutions.

Key article trends (2018-2025) reveal expertise in:

• Transcriptional condensates
• PAX3-FOXO1 fusion mechanisms
• Super-enhancer biology
• RNA Pol2 cluster dynamics
• Epigenetic plasticity in resistance
• 3D genomics technologies (AQuA-HiChIP)