Bastien Castagner

Bastien Castagner is an Associate Professor in the Department of Pharmacology & Therapeutics at McGill University. His research bridges chemical biology, microbiology, and pharmacology to develop novel therapeutic strategies targeting Clostridioides difficile toxins and the human gut microbiota, particularly in the context of cancer immunotherapy.

• McIntyre Medical Sciences Building, Room 1312A, Montreal, QC
• Joined McGill in 2014; promoted to Associate Professor in 2020

His team employs a multidisciplinary approach, collaborating with experts in microbiology, structural biology, computational chemistry, bioinformatics, and oncology. Key research areas include:

• Design of small-molecule and natural product analogues as drug candidates
• Chemistry and biology of inositol phosphates and carbohydrates
• Novel strategies to inactivate C. difficile toxins
• Prebiotic approaches using glycans and polyphenols to modulate gut microbiota
• Improving cancer immunotherapy efficacy through microbiota manipulation

The lab's recent publications highlight advancements in thiophosphate inositol derivatives, urolithin A metabolism, and gut microbiome modulation. Despite no explicit mentions of formal awards or students in the provided texts, his work demonstrates significant translational potential in antimicrobial and oncological applications.