Philippe Langella

Philippe Langella is a distinguished Director of Research at INRAE and leader of the Commensals and Probiotics-Host Interactions (ProbiHôte) team at the Microbiology of Human Health Laboratory (MICALIS, Université Paris-Saclay). His career spans groundbreaking work on probiotics, intestinal microbiota, and host-microbe interactions, with major discoveries in genetically modified lactic acid bacteria for HPV antigen delivery and the identification of Faecalibacterium prausnitzii (Fprau) as a next-generation probiotic for inflammatory bowel disease.

• PhD in industrial microbiology, Rennes
• Co-founder of Exeliom Biosciences (€27M raised)
• 2023 INRAE Grand Prix des Lauriers awardee
• Pioneered collaborations between academia and industry (Danone, Biocodex)

His research focuses on:

• Therapeutic potential of probiotics in murine colitis models
• Microbiota dynamics during the first 1,000 days of life
• Prebiotic dietary fibers for microbiota modulation

Scientific awards:

• 2023: INRAE Grand Prix des Lauriers for scientific excellence

His entrepreneurial endeavors include co-founding Exeliom Biosciences to develop Fprau as a drug candidate for IBD and Clostridioides difficile infections. The team also investigates microbiota transmission from mother to child, with applications in neonatal health.