معرفی
Bart Ghesquière is a Full Professor at the Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, and heads the Metabolomics Expertise Center at the VIB-KU Leuven Center for Cancer Biology. He leads the Laboratory of Applied Mass Spectrometry (LAMaS) and serves as head of the Proteomics Core Facility at KU Leuven. His leadership extends to multiple research initiatives including membership in the VIB-KU Leuven Center for Cancer Biology, LISCO (KU Leuven Institute for Single Cell Omics), and LKI (KU Leuven Cancer Institute. He also participates in institutional governance as a member of the Council of the Faculty of Medicine and the Council of the Department of Cellular and Molecular Medicine.
Dr. Ghesquière's research focuses on metabolomics, mass spectrometry, biochemistry, and stable isotope tracing. His work centers on tracer metabolomics, which provides comprehensive insights into metabolic pathways ('Google Maps of Biochemistry'), revealing both the activity and interconnectivity of biochemical pathways across diverse biological contexts. His laboratory develops novel mass spectrometry-based technologies while applying them to study metabolic disorders and syndromes, with particular emphasis on congenital disorders of glycosylation, mitochondrial disorders, and organ metabolism during transplantation procedures.
His scientific contributions include the development of innovative tools like TraVis Pies for stable isotope metabolomics interpretation and significant discoveries in metabolic pathways related to glycosylation disorders, kidney perfusion, and cellular metabolism under stress conditions. His work has been published in high-impact journals including Nature, Cell Reports, and American Journal of Human Genetics.
- Orloff Science award (received during his work at NIH)
Dr. Ghesquière currently leads a team of 11 researchers including a project manager, expert technicians, senior postdoctoral scientists, data analysts, and PhD students. He serves as promotor for two PhD students and co-promotor for three others. His research is supported by multiple ongoing projects including studies on de novo serine biosynthesis in obesity-induced cardiomyocyte dysfunction, short chain fatty acids in hepatic lipid metabolism, and nuclear metabolism in cancer cells under hypoxia. His laboratory provides metabolomics services to research groups while developing novel technologies and biological applications.
The Metabolomics Expertise Center under Dr. Ghesquière's leadership functions as both a service facility for metabolomics-oriented research groups and an innovative research hub developing cutting-edge technologies in tracer metabolomics. His team has developed specialized software like MAIMS for metabolic tracer analysis and continues to advance hardware and methodology in the field. The laboratory maintains strong collaborations across multiple disciplines, particularly in cancer biology, transplantation medicine, and rare metabolic disorders.
