Attila A. Seyhan

Attila A. Seyhan is an Adjunct Associate Professor of Pathology and Laboratory Medicine at the Warren Alpert Medical School, Brown University. He serves as Director of Translational Oncology Operations at the Brown University Cancer Center and Lifespan Health System. His career spans academia (Brown University, Fox Chase Cancer Center, Florida Hospital, Sanford Burnham Prebys), pharmaceutical sectors (Pfizer, Wyeth), and biotechnology (Open Biosystems, Dharmacon). His collaborative efforts bridge clinicians, scientists, regulatory teams, and industry partners.

• Education: PhD in Biological Sciences (NATO Science Fellowship) from Michigan Technological University (1993), BS in Biology from Hacettepe University (1986).
• Postdoctoral Training: Ferritin gene regulation at University of Paris VII (1993-1995); Hairpin ribozyme biochemistry at University of Vermont (1995-1999).

Research Interests: Focused on RNA biology, epigenetics, and translational oncology. Key areas include RNA therapeutics (siRNA, miRNA, ribozymes), cancer drug resistance mechanisms, and biomarker discovery for autoimmune/metabolic diseases. His work spans glioblastoma, prostate cancer, colorectal cancer, and pancreatic cancer.

Article Trends: Recent publications emphasize drug synergy (ONC201/206 with HDAC/AR inhibitors), TRAIL pathway modulation, liquid biopsy biomarkers (miRNA in GBM, diabetes, lupus), and overcoming translational research barriers. Topics intersect epigenetics, immunotherapy, and AI in precision medicine.

Scientific Awards:

• NATO Science Fellowship (1988-1991)
• Young Investigator Award (1999)
• Pfizer Excellence Awards (2013)
• CalTIP Award (2000)
• Wyeth/Pfizer Long-Term Incentive Plan (2009-2012)
• Florida Hospital Certificate of Appreciation (2014)

Advising & Grants: As PI/co-PI, he secured NIH/DOD funding for RNAi/shRNA libraries, epigenetic cancer targets, and diabetes biomarkers. His work led to patents (e.g., miRNA-based therapies) and influenced clinical trials (neratinib/paclitaxel combination).

Labs & Teams: Leads the Translational Oncology Operations at Brown University Cancer Center. Previously directed Functional Genomics at Wyeth/Pfizer and Translational Research at Florida Hospital. Collaborates with multi-institutional teams (Brown, MIT, Sanford Burnham Prebys).