معرفی
Jianfei Qi, PhD, is an Associate Professor in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine, conducting critical research on prostate cancer progression and therapeutic resistance mechanisms.
Education:
- Ph.D. in Biochemistry, Toronto University (2006)
- Postdoctoral Fellow, Sanford-Burnham Medical Research Institute (2010)
- Staff Scientist, Sanford-Burnham Medical Research Institute (2013)
Research Focus: Dr. Qi's work centers on prostate cancer molecular mechanisms, with deep expertise in epigenetics and transcriptional regulation. His laboratory investigates histone demethylases (JMJD1A), ubiquitin ligases (STUB1, Siah2), and oncogenic transcription factors (androgen receptor, c-Myc) using transgenic mouse models (PTEN/Hi-Myc) and genome-wide approaches (RNA-seq, ChIP-seq, ATAC-seq).
Publication Trends: Recent work (2018-2023) demonstrates how epigenetic regulators and ubiquitination pathways converge to drive castration resistance, particularly through AR-V7 splicing, JMJD1A stabilization, and SMAD3-mediated androgen receptor activation. His research consistently identifies novel therapeutic targets for advanced prostate cancer.
Collaborations: Maintains stable partnerships with prostate cancer pathology and systems biology experts to enhance translational impact of findings.
Advising and Grants: The provided information does not specify student advisees or grant funding details.
