Aslı Kumbasar

Aslı Kumbasar serves as faculty in the Department of Molecular Biology and Genetics at Istanbul Technical University, where her research centers on transcription factor mechanisms in cancer and neural development. With 13 publications spanning three decades and 15 funded research projects, she maintains an active program investigating Nuclear Factor I (NFI) family proteins.

Her research profile features:

• Transcriptional regulation of neuroblastoma and glioblastoma
• Molecular interactions of NFI proteins with PIN1 and CDON
• Glypican and heparan sulfate proteoglycan biology
• VEGF signaling and angiogenesis inhibition
• Neural development pathways
• Cancer cell survival mechanisms

Recent publications (2022-2025) reveal critical NFI roles in SH-SY5Y neuroblastoma survival and glioblastoma progression, with emerging work on PIN1-NFIB interactions. Her fingerprint analysis confirms specialization in transcription factors (80%), cell surface proteoglycans (77%), and glypican biology (75%).

As Principal Investigator on 15 projects including current TUSEB-funded neuroblastoma research (2024-2025), she directs investigations into NFIB-regulated genes and SUMO1-NFI interactions in glioblastoma. Her supervised work encompasses 13 mentored researchers, with ongoing projects examining phospho-motifs on NFIB and microRNA targeting of NFIX.