معرفی
Dr. Arthur Brown is a Professor and Associate Chair (Research) in the Department of Anatomy and Cell Biology at Western University's Schulich School of Medicine & Dentistry, and a Principal Investigator at the Robarts Research Institute. His work focuses on understanding the molecular mechanisms of spinal cord injury, leveraging expertise in neurodevelopment, regenerative medicine, and molecular biology. He leads therapeutic strategies to enhance recovery by balancing pro- and anti-regenerative processes, including gene therapy and stem cell transplantation.
Education: Dr. Brown earned a Ph.D. in Medical and Molecular Genetics from the University of Toronto and a B.Sc. from the University of Calgary. He completed postdoctoral training in Neurodegeneration at the Institut du Cancer (Montreal, QC) and Neurodevelopment at the Salk Institute (San Diego, CA).
Research Interests: His primary research explores how Eph receptors guide nervous system development and influence cardiac morphogenesis. More recently, he investigates the role of embryonic genetic programs in spinal cord regeneration, targeting inhibitory scar genes (e.g., SOX9) and leveraging stem cells to rejuvenate damaged tissues. He also studies neuroinflammation, particularly the dual role of inflammatory responses in injury and repair.
- Key Projects: Manipulating gene expression to upregulate pro-regenerative genes, bone marrow-derived stem cell therapies, and CD11d monoclonal antibody treatments.
- Collaborations: Works with Weaver and Dekaban labs on neuroprotective strategies and antibody therapies.
Scientific Awards & Grants:
- Heart and Stroke Foundation of Canada New Investigator’s Award
- CIHR Grant: SOX9 regulation of scar production after spinal cord injury
- CIHR Grant: Leukocyte integrins as neuroprotective targets after SCI
- Morton Cure Paralysis Fund: Identifying SOX9 inhibitors
- International Fund for Paralysis Research: SOX9 knockout mouse studies
Advising & Grants: Dr. Brown has supervised multiple research projects funded by major grants, focusing on spinal cord injury therapies. His grants support experimental models (rat, mouse, primate) and clinical translation. No formal advisee names are listed in the provided texts.
Labs & Teams: Based at the Robarts Research Institute, he leads a team investigating nervous system regeneration and molecular controls of cell behavior. His lab collaborates with imaging and molecular medicine groups to advance translational neuroscience.
